RS 79948 hydrochloride

Cat. No. 0987

RS 79948 hydrochloride C19H28N2O3S.HCl [186002-54-0]

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Chemical Name: (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride

Biological Activity

α2-adrenoreceptor antagonist (Kd values are; 0.18, 0.19 and 0.42 nM for α2B α2C and α2A, respectively in rat).

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M.Wt:
400.96
Formula:
C19H28N2O3S.HCl
Solubility:
Soluble to 25 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
186002-54-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Uhlen et al (1998) [3H]RS79948-197 binding to rat, guinea pig and pig α2A-, α2B and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93. PMID: 9551719.

Hume et al (1996) Evaluation in rat of RS-79948-197 as a potential PET ligand for central α2-adrenoceptors. Eur.J.Pharmacol. 317 67. PMID: 8982721.

Clark et al (1989) (8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]-naphthyridine, a potent and highly selective α2-adrenoceptor antagonist. J. Med. Chem. 32 2034. PMID: 2570150.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for RS 79948 hydrochloride include:

Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969. PMID: 23776582.

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