Cat. No. 0995
Chemical Name: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1
Biological Activity5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Antipsychotic.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. PMID: 7938165.
Seeman and van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264. PMID: 7940991.
Merck Index 12 8903.
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Citations are publications that use Tocris products. Selected citations for Spiperone hydrochloride include:
Nickla et al (2010) Dopaminergic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicks. Exp Eye Res 91 715. PMID: 20801115.
Zapata et al (2007) Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem 282 35842. PMID: 17923483.
Meredith et al (2006) Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma. Proc Natl Acad Sci U S A 103 13485. PMID: 16938864.
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Keywords: Spiperone hydrochloride, supplier, D2-like, antagonists, 5-HT2A, Dopamine, Non-Selective, Receptors, Serotonin, dopaminergic, Tocris Bioscience, 5-HT2A Receptor Antagonist products