Cat. No. 0984
Chemical Name: (2S)-(+)-5,5-Dimethyl-2-morpholinea
Biological ActivityA selective, competitive and orally active GABAB antagonist. Displays an IC50 of 1.1 μM at GABAB, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABAA at concentrations up to 100 μM.
Licensing InformationSold with the permission of Schering Plough Corporation
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ong et al (1998) The morpholino-acetic acid analogue Sch 50911 is a selective GABAB receptor antagonist in rat neocortical slices. Eur.J.Pharmacol. 362 35. PMID: 9865527.
Blythin et al (1996) Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABAB antagonists. Bioorg.Med.Chem.Lett. 6 1529.
Bolser et al (1995) The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. J.Pharmacol.Exp.Ther. 274 1393. PMID: 7562513.
Hosford et al (1995) Characterization of the antiabsence effects of SCH 50911, a GABAB receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J.Pharmacol. Exp.Ther. 274 1399. PMID: 7562514.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for SCH 50911 include:
Fritsch et al (2009) Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis. Neuroscience 163 415. PMID: 19540312.
Kitagawa et al (2009) Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Mol Syst Biol 5 280. PMID: 19536203.
Vogt and Nicoll (1999) Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus. Proc Natl Acad Sci U S A 96 1118. PMID: 9927703.
Do you know of a great paper that uses SCH 50911 from Tocris? If so please let us know.
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Keywords: SCH 50911, supplier, Selective, competitive, orally, active, GABAB, antagonist, Receptors, SCH50911, Tocris Bioscience, GABAB Receptor Antagonist products
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