VUF 5574

Cat. No. 1359

VUF 5574 C21H17N5O2 [280570-45-8]

Price and Availability

For VUF 5574 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-(2-Methoxyphenyl)-N'-[2-(3-pyrindinyl)-4-quinazolinyl]-urea

Biological Activity

Potent, selective, competitive antagonist for the human adenosine A3 receptor (Ki = 4 nM). Displays ≥ 2500-fold selectivity over A1 and A2A receptors.

Technical Data

M.Wt:
371.39
Formula:
C21H17N5O2
Solubility:
Soluble to 4 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
280570-45-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456. PMID: 11121831.

van Muijlwijk-Koezen et al (2000) Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor. J.Med.Chem. 43 2227. PMID: 10841801.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for VUF 5574 include:

Hua et al (2011) IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One 6 e24947. PMID: 21966389.

Pugliese et al (2006) A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro. Br J Pharmacol 147 524. PMID: 16415905.

Do you know of a great paper that uses VUF 5574 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: VUF 5574, supplier, Potent, selective, hA3, antagonists, Receptors, adenosines, VUF5574, Tocris Bioscience, Adenosine A3 Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

divider line

New Products in this Area

ISAM 140

High affinity A2B receptor antagonist

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.