VUF 5574

Cat. No. 1359

VUF 5574 C21H17N5O2 [280570-45-8]

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Chemical Name: N-(2-Methoxyphenyl)-N'-[2-(3-pyrindinyl)-4-quinazolinyl]-urea

Biological Activity

Potent, selective, competitive antagonist for the human adenosine A3 receptor (Ki = 4 nM). Displays ≥ 2500-fold selectivity over A1 and A2A receptors.

Technical Data

Soluble to 4 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456. PMID: 11121831.

van Muijlwijk-Koezen et al (2000) Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor. J.Med.Chem. 43 2227. PMID: 10841801.

If you know of a relevant reference for VUF 5574 please let us know.

Citations are publications that use Tocris products. Selected citations for VUF 5574 include:

Hua et al (2011) IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One 6 e24947. PMID: 21966389.

Pugliese et al (2006) A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro. Br J Pharmacol 147 524. PMID: 16415905.

Do you know of a great paper that uses VUF 5574 from Tocris? If so please let us know.

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Keywords: VUF 5574, supplier, Potent, selective, hA3, antagonists, Receptors, adenosines, VUF5574, Tocris Bioscience, Adenosine A3 Receptor Antagonist products

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