Cat. No. 0970
Chemical Name: 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl
Biological ActivitySelective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (Ki = 3.4 μM). Antifungal antibiotic.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Christner et al (1999) Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J.Med.Chem. 42 3615. PMID: 10479292.
Tang et al (1999) Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism. J.Biol.Chem. 274 7245. PMID: 10066786.
Obrig et al (1971) The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. J.Biol.Chem. 246 174. PMID: 5541758.
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Citations are publications that use Tocris products. Selected citations for Cycloheximide include:
Wiedermann et al (2015) A balance of positive and negative regulators determines the pace of the segmentation clock. Elife 4. PMID: 26357015.
Bhatnagar et al (2014) Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. J Biol Chem 289 25276. PMID: 25002582.
Wang et al (2014) A molecular brake controls the magnitude of long-term potentiation. Nat Commun 5 3051. PMID: 24394804.
Pont et al (2012) Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol.Endocrinol. 26 1743. PMID: 22902539.
Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228. PMID: 19096033.
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Keywords: Cycloheximide, supplier, inhibitors, inhibits, protein, synthesis, Antifungal, antibiotics, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
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