Cycloheximide

Cat. No. 0970

Cycloheximide C15H23NO4 [66-81-9]

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Chemical Name: 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione

Biological Activity

Selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (Ki = 3.4 μM). Antifungal antibiotic.

Technical Data

M.Wt:
281.35
Formula:
C15H23NO4
Solubility:
Soluble to 50 mM in ethanol and to 25 mM in water
Purity:
>97 %
Storage:
Desiccate at RT
CAS No:
66-81-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Christner et al (1999) Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J.Med.Chem. 42 3615. PMID: 10479292.

Tang et al (1999) Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism. J.Biol.Chem. 274 7245. PMID: 10066786.

Obrig et al (1971) The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. J.Biol.Chem. 246 174. PMID: 5541758.

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Citations are publications that use Tocris products. Selected citations for Cycloheximide include:

Di et al (2016) Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. J.Neurosci. 36 8461. PMID: 27511017 .

Briz et al (2015) Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. Neurobiol Dis 35 2269. PMID: 25653381.

Wiedermann et al (2015) A balance of positive and negative regulators determines the pace of the segmentation clock. Elife 4. PMID: 26357015.

Bhatnagar et al (2014) Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. J Biol Chem 289 25276. PMID: 25002582.

Wang et al (2014) A molecular brake controls the magnitude of long-term potentiation. Nat Commun 5 3051. PMID: 24394804.

Bernard et al (2013) Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. J Appl Physiol (1985) 59 42736. PMID: 23831253.

Pont et al (2012) Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol.Endocrinol. 26 1743. PMID: 22902539.

Argadine et al (2009) The effect of denervation on protein synthesis and degradation in adult rat diaphragm muscle. J Neurosci 107 438. PMID: 19520837.

Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228. PMID: 19096033.

Chan et al (2007) Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death. J Neurosci 282 4585. PMID: 17150954.

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Keywords: Cycloheximide, supplier, inhibitors, inhibits, protein, synthesis, Antifungal, antibiotics, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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