Cat. No. 3555
Alternative Name: Calcitonin receptor-stimulating peptide-1
Biological ActivityEndogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin receptors. Inhibits formation of multinuclear osteoclasts with similar efficacy to CT in vitro. Suppresses food intake and increases body temperature in free-feeding rats, and significantly decreases plasma calcium levels in vivo.
(Modifications: Disulfide bridge between 2 - 7, Gly-38 = C-terminal amide)
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Notoya et al (2007) A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts. Eur.J.Pharmacol. 560 234. PMID: 17328890.
Sawada et al (2006) Central effects of calcitonin receptor-stimulating peptide-1 on energy homeostasis in rats. Endocrinology 147 2043. PMID: 16410305.
Katafuchi et al (2003) Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity. J.Biol.Chem. 278 12046. PMID: 12556539.
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Keywords: CRSP-1, supplier, Endogenous, central, CT, receptors, calcitonin, agonists, Calcitonin, receptor, stimulating, peptide1, Tocris Bioscience, Calcitonin and Related Receptor Agonist products
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