Parstatin (human)

Cat. No. 3553

Parstatin (human) Met-Gly-Pro-Arg-Arg-Leu-Leu-Leu-Val-Ala-Ala-Cys-Phe-Ser-Leu-Cys-Gly-Pro-Leu-Leu-Ser-Ala-Arg-Thr-Arg-Ala-Arg-Arg-Pro-Glu-Ser-Lys-Ala-Thr-Asn-Ala-Thr-Leu-Asp-Pro-Arg

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Biological Activity

Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apoptotic activity in vitro. Inhibits angiogenesis and exhibits cardioprotective activity in vivo.

Technical Data

M.Wt:
4467.29
Formula:
C191H330N64O53S3
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPR
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1065755-99-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Strande et al (2009) Parstatin: a cryptic peptide involved in cardioprotection after ischaemic and reperfusion injury. Cardiovasc.Res. 83 325. PMID: 19380418.

Zania et al (2009) Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of activation. J.Pharmacol.Exp.Ther. 328 378. PMID: 18988770.

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Keywords: Parstatin (human), supplier, Peptide, cleaved, PAR1, receptors, activation, Protease-Activated, proteinase-activated, Tocris Bioscience, Protease-Activated Receptor products

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