Tacrine hydrochloride

Cat. No. 0965

Tacrine hydrochloride C13H14N2.HCl [1684-40-8]

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Chemical Name: 1,2,3,4-Tetrahydro-5-aminoacridine hydrochloride

Biological Activity

Potent cholinesterase inhibitor, a cognition enhancer in vivo.

Technical Data

M.Wt:
234.73
Formula:
C13H14N2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
1684-40-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Snape et al (1999) A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology 38 181. PMID: 10193909.

Osborne and Christie (1996) Tetrahydro-9-aminoacridine has mixed actions on muscarinic currents and blocks opioid currents in rat locus ceruleus neurons. J.Pharmacol.Exp.Ther. 276 137. PMID: 8558423.

Freeman and Dawson (1991) Tacrine: a pharmacological review. Prog.Neurobiol. 36 257. PMID: 1714613.

Summers and Kaufman (1980) THA- A review of the literature and its use in treatment of five overdose patients. Clin.Toxicol. 16 269. PMID: 6994999.

Merck Index 12 9199.

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Citations are publications that use Tocris products. Selected citations for Tacrine hydrochloride include:

Rio et al (2010) M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes. Mol Cell Endocrinol 30 6011. PMID: 20427660.

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Keywords: Tacrine hydrochloride, supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, Tocris Bioscience, Cholinesterase Inhibitor products

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