Cat. No. 0964

Diazoxide C8H7ClN2O2S [364-98-7]

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Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

Biological Activity

Antihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Kim et al (2006) Diazoxide acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059. PMID: 17043673.

Yamada and Rothman (1992) Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409. PMID: 1302270.

Trube et al (1986) Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493. PMID: 2431383.

Merck Index 12 3051.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Diazoxide include:

Cox et al (2014) Chronic neonatal diazoxide therapy is not associated with adverse effects J Neurosci 14 49. PMID: 25587244.

Do you know of a great paper that uses Diazoxide from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Diazoxide, supplier, Blocks, desensitization, desensitisation, AMPA, receptors, K+, channel, opener, KATP, Glutamate, Receptors, iGlur, Ionotropic, Potassium, KIR, Kir6, Channels, Inward, Rectifier, Tocris Bioscience, AMPA Receptor products

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