Cat. No. 3549
Chemical Name: (1R,5S)-9-Bromo-1,2,3,4,5,6-hexahyd
Biological ActivityPotent agonist of α4β4, α4β2 and α7 nACh receptors (IC50 values are 0.28, 0.30 and 31.6 nM respectively). Displays different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs (EC50 values are 0.008 and 0.05 μM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Moroni et al (2006) α4β2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol.Pharmacol. 70 755. PMID: 16720757.
Houlihan et al (2001) Activity of cytisine and its brominated isoteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors. J.Neurochem. 78 1029. PMID: 11553677.
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Citations are publications that use Tocris products. Selected citations for 3-Bromocytisine include:
Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538. PMID: 25303328.
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Keywords: 3-Bromocytisine, supplier, 3-Br-Cytisine, nACh, receptor, agonist, nicotinic, acetylcholine, receptors, a4b4, a4b2, a7, agonists, alpha4beta4, alpha4beta2, alpha7, Tocris Bioscience, Nicotinic Receptor (Non-selective) Agonist products