INH1

Cat. No. 3551

INH1 C18H16N2OS.HCl [313553-47-8]

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Chemical Name: N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide hydrochloride

Biological Activity

Hec1 inhibitor. Binds Hec1, inhibiting its association with Nek2 and kinetochores. Causes arrest of mitosis and inhibits proliferation in breast cancer cell lines (GI50= 10 - 20 μM).

Technical Data

M.Wt:
344.86
Formula:
C18H16N2OS.HCl
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
313553-47-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wu et al (2008) Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 68 8393. PMID: 18922912.

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Citations are publications that use Tocris products. Selected citations for INH1 include:

Linton et al (2014) An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma. Br J Cancer 110 510. PMID: 24327015.

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Keywords: INH1, supplier, Hec1, inhibitors, inhibits, mitosis, arrests, Tocris Bioscience, Mitosis products

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