SCH 23390 hydrochloride

Cat. No. 0925

SCH 23390 hydrochloride C17H18ClNO.HCl [125941-87-9]

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Alternative Name: (R)-(+)-SCH 23390 hydrochloride

Chemical Name: (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Biological Activity

Potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.

Technical Data

M.Wt:
324.24
Formula:
C17H18ClNO.HCl
Solubility:
Soluble to 100 mM in water with gentle warming and to 50 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
125941-87-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Kuzhikandathil and Oxford (2002) Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol.Pharmacol. 62 119. PMID: 12065762.

Bourne et al (2001) SCH 23390: The first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 7 399. PMID: 11830757.

Millan et al (2001) The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist against cloned human serotonin2C receptors. Psychopharmacology 156 58. PMID: 11465634.

Briggs et al (1991) Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038. PMID: 1687364.

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Citations are publications that use Tocris products. Selected citations for SCH 23390 hydrochloride include:

Brzosko et al (2015) Retroactive modulation of spike timing-dependent plasticity by dopamine. Elife 4. PMID: 26516682.

Hao et al (2015) L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway. Cell Death Dis 6 e1965. PMID: 26539912.

Meunier et al (2015) Effect of dopaminergic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex. PLoS One 10 e0120286. PMID: 25775449.

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192. PMID: 26074768.

Marcott et al (2014) Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron 84 164. PMID: 25242218.

Jia et al (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16 1627. PMID: 24121738.

Zhang et al (2013) Sucrose produces withdrawal and dopamine-sensitive reinforcing effects in planarians. Physiol Behav 112-113 8. PMID: 23415661.

Lisek et al (2012) Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation. Drug Alcohol Depend 126 257. PMID: 22652295.

Krishnan et al (2010) Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal. Eur J Neurosci 31 1027. PMID: 20377617.

Raghuraman et al (2010) Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling. J Neurochem 115 1568. PMID: 20969567.

Chuhma et al (2009) Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068. PMID: 19729052.

Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040. PMID: 18685029.

Witkovsky et al (2007) Cellular localization and function of DARPP-32 in the rodent retina. Eur J Neurosci 25 3233. PMID: 17552992.

Meredith et al (2006) Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma. Proc Natl Acad Sci U S A 103 13485. PMID: 16938864.

Do you know of a great paper that uses SCH 23390 hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: SCH 23390 hydrochloride, supplier, 5-HT2C, agonists, potent, D1-like, antagonists, selective, Serotonin, Receptors, Dopamine, D1, D5, dopaminergic, SCH23390, hydrochloride, Tocris Bioscience, D1 and D5 Receptor Antagonist products

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