CP 316819

Cat. No. 3542

CP 316819 C21H22ClN3O4 [186392-43-8]

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Chemical Name: 5-Chloro-N-[(1S,2R)-2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide

Biological Activity

Selective glycogen phosphorylase inhibitor [IC50 values are 0.017 and 0.034 μM against human skeletal muscle glycogen phosphorylase a (huSMGPa) and liver glycogen phosphorylase a (huLGPa) respectively]. Antihyperglycemic agent.

Technical Data

M.Wt:
415.87
Formula:
C21H22ClN3O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
186392-43-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Suh et al (2007) Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide). J.Pharmacol.Exp.Ther. 321 45. PMID: 17251391.

Freeman et al (2006) Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation site of the enzyme. Br.J.Pharmacol. 149 775. PMID: 17016495.

Baker et al (2005) Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle. Diabetes 54 2453. PMID: 16046314.

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Citations are publications that use Tocris products. Selected citations for CP 316819 include:

Galow et al (2014) Energy substrates that fuel fast neuronal network oscillations. J Exp Bot 8 398. PMID: 25538552.

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Keywords: CP 316819, supplier, glycogen, phosphorylase, inhibitors, inhibits, antihyperglycemic, antihyperglycaemic, transferases, carbohydrate, metabolism, CP316819, Tocris Bioscience, Phosphorylase Inhibitor products

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