BAY-X 1005

Cat. No. 3541

BAY-X 1005 C23H23NO3 [128253-31-6]

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Chemical Name: (R)-α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid

Biological Activity

5-lipoxygenase activating protein (FLAP) inhibitor. Inhibits the synthesis of leukotrienes B4 and C4 in animal models; inhibits synthesis of leukotriene B4 in A23187-stimulated leukocytes (IC50 values are 0.026, 0.039 and 0.22 μM for rat, mice and human leukocytes respectively). Displays anti-inflammatory activity. Orally active.

Technical Data

M.Wt:
361.43
Formula:
C23H23NO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
128253-31-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hatzelmann et al (1994) Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions 43 64. PMID: 7741044.

Fruchtmann et al (1993) In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis. Agents Actions 38 188. PMID: 8213345.

Muller-Peddinghaus et al (1993) BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. J.Pharmacol.Exp.Ther. 267 51. PMID: 8229782.

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Keywords: BAY-X 1005, supplier, BAY-X1005, 5-lipoxygenase, activating, protein, FLAP, inhibitors, inhibits, leukotriene, synthesis, signaling, signalling, inhibitors, inhibits, antiinflammatory, 5-LOX, Tocris Bioscience, Lipoxygenase Inhibitor products

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