(-)-Nicotine ditartrate

Cat. No. 3546

(-)-Nicotine ditartrate C10H14N2.2C4H6O6 [65-31-6]

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Chemical Name: (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt

Biological Activity

Nicotinic acetylcholine receptor (nAChR) agonist (Ki values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.

Technical Data

Soluble to 100 mM in water and to 75 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Mayhan (1999) Acute infusion of nicotine potentiates norepinephrine-induced vasoconstriction in the hamster cheek pouch. J.Lab.Clin.Med. 133 48. PMID: 10385481.

Donnelly-Roberts et al (1998) ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization. J.Pharmacol.Exp.Ther. 285 777. PMID: 9580626.

Xiao et al (1998) Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function. Mol.Pharmacol. 54 322. PMID: 9687574.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (-)-Nicotine ditartrate include:

Miguel Angel Garcia-Bereguiain et al (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience 6 7268. PMID: 27383600.

Chalabi-Yani et al (2015) Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats. Elife 19 214. PMID: 26210948.

Tang et al (2015) Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B. Iran Biomed J 36 800. PMID: 25948478.

Leão et al (2012) OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci 15 1524. PMID: 23042082.

Owaisat et al (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525 12. PMID: 22877698.

Do you know of a great paper that uses (-)-Nicotine ditartrate from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: (-)-Nicotine ditartrate, supplier, α4β2, agonists, a4b2, alpha4beta2, Nicotinic, Receptors, Acetylcholine, nAChR, Tocris Bioscience, Nicotinic Receptor (Non-selective) Agonist products

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