Cat. No. 1004
Chemical Name: 5-(4-Chlorophenyl)-4-methyl-3-(1-(2
Biological ActivityA potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.
Licensing InformationSold with the permission of Merck Sharp and Dohme Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Rowley et al (1997) 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor. J.Med.Chem. 40 2374. PMID: 9240352.
Rowley et al (1996) 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors. J. Med. Chem. 39 1943. PMID: 8642551.
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Citations are publications that use Tocris products. Selected citations for L-741,742 hydrochloride include:
Root et al (2015) Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci 35 3460. PMID: 25716845.
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Keywords: L-741,742 hydrochloride, supplier, selective, D4, antagonists, Dopamine, Receptors, dopaminergic, L741742, Tocris Bioscience, D4 Receptor Antagonist products