L-741,742 hydrochloride

Cat. No. 1004

L-741,742 hydrochloride C23H25N2ClO.HCl [874882-93-6]

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Chemical Name: 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride

Biological Activity

A potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M.Wt:
417.38
Formula:
C23H25N2ClO.HCl
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
874882-93-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Rowley et al (1997) 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor. J.Med.Chem. 40 2374. PMID: 9240352.

Rowley et al (1996) 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors. J. Med. Chem. 39 1943. PMID: 8642551.

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Keywords: L-741,742 hydrochloride, supplier, selective, D4, antagonists, Dopamine, Receptors, dopaminergic, L741742, Tocris Bioscience, D4 Receptor Antagonist products

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