RS 17053 hydrochloride
Cat. No. 0985
Chemical Name: (N-[2-(2-Cyclopropylmethoxyphenoxy)
Biological Activityα1A-adrenoceptor antagonist, with very high affinity for α1A receptors (pKi and pA2 estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α1B and α1D subtypes (pKi and pA2 estimates 7.7 - 7.8).
Licensing InformationSold with the permission of Roche Bioscience
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ford et al (1996) RS 17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine hydrochloride, a selective α1A-adrenoceptor antagonist, displays low affinity for functional α1-adrenoceptors in human prostate: implications for adrenoceptor classification. Mol.Pharmacol. 49 209. PMID: 8632751.
Marshall et al (1996) Different subtypes of α1A-adrenoceptor mediating contraction of rat epididymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonist RS 17053. Br.J.Pharmacol. 119 407. PMID: 8886428.
Ford et al (1995) Do α1A (α1C)-adrenoceptors (AR) mediate prostatic smooth muscle contraction in man? Studies with a novel, selective α1A-AR antagonist, RS 17053. Br.J.Pharmacol. 114 C25.
If you know of a relevant reference for RS 17053 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses RS 17053 hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: RS 17053 hydrochloride, supplier, α1A-adrenoceptor, alpha1A-adrenoceptor, α1-adrenergic, alpha1-adrenergic, a1-adrenoceptor, a1-adrenergic, antagonists, receptors, RS17053, hydrochloride, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products