CGP 46381

Cat. No. 1247

CGP 46381 C10H22NO2P [123691-14-5]

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Chemical Name: (3-Aminopropyl)(cyclohexylmethyl)phosphinic acid

Biological Activity

Brain penetrant, selective GABAB receptor antagonist (IC50 = 4.9 μM).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M.Wt:
219.26
Formula:
C10H22NO2P
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
123691-14-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Staubli et al (1999) GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 19 4609. PMID: 10341258.

Curtis and Lacey (1998) Prolonged GABAB receptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study. Exp.Brain Res. 121 319. PMID: 9746138.

Froestl et al (1996) Potent, orally active GABAB receptor antagonists. Pharmacol.Rev.Comm. 8 127.

Lingenhoehl and Olpe (1993) Blockade of the late inhibitory postsynaptic potential in vivo by the GABAB antagonist CGP 46381. Pharmacol.Comm. 3 49.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CGP 46381 include:

Cheng et al (2015) GABAB receptor antagonist CGP46381 inhibits form-deprivation myopia development in guinea pigs. Front Cell Neurosci 2015 207312. PMID: 25649745.

Lee and Sherman (2012) Intrinsic modulators of auditory thalamocortical transmission. Hear Res 287 43. PMID: 22726616.

Pacey et al (2011) Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. Biomed Res Int 338 897. PMID: 21636656.

Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040. PMID: 18685029.

Do you know of a great paper that uses CGP 46381 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: CGP 46381, supplier, Brain, penetrant, selective, GABAB, antagonist, Receptors, CGP46381, Tocris Bioscience, GABAB Receptor Antagonist products

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