CGP 52432

Cat. No. 1246

CGP 52432 C15H24Cl2NO4P [139667-74-6]

Price and Availability

For CGP 52432 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid

Biological Activity

Potent, selective GABAB receptor antagonist (IC50 = 85 nM).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M.Wt:
384.24
Formula:
C15H24Cl2NO4P
Solubility:
Soluble to 10 mM in water with sonication and to 100 mM in 1eq. NaOH
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
139667-74-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Bonanno et al (1998) GABAB receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord. Eur.J.Pharmacol. 362 143. PMID: 9874164.

Libri et al (1998) Blockade of GABAB receptors facilitates muscarinic agonist-induced epileptiform activity in immature rat piriform cortex in vitro. Naunyn Schmiedebergs Arch.Pharmacol. 358 168. PMID: 9750001.

Froestl et al (1996) Potent, orally active GABAB receptor antagonists. Pharmacol.Rev.Comm. 8 127.

Lanza et al (1993) CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Eur.J.Pharmacol. 237 191. PMID: 8103461.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CGP 52432 include:

Bragina et al (2015) Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9 345. PMID: 26388733.

Lee et al (2015) Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat. Neural Plast 2015 924728. PMID: 26451259.

Mans et al (2014) An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol 112 2388. PMID: 25143547.

Song et al (2013) Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources. Front Cell Neurosci 7 23. PMID: 23494150.

Venkataraman and Bartlett (2013) Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus. J Neurophysiol 109 2866. PMID: 23536710.

Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285. PMID: 22368777.

Parker et al (2011) Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice. J Neurosci 31 17103. PMID: 22114279.

Moore et al (2009) Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors. Neuron 61 287. PMID: 19186170.

Do you know of a great paper that uses CGP 52432 from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: CGP 52432, supplier, Potent, selective, GABAB, antagonists, Receptors, CGP52432, Tocris Bioscience, GABAB Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

divider line

GABA Review

Written by I. Martin et al

GABA Receptors Scientific Review

Our GABA review gives an overview of the structure and function of the GABA receptors, as well as highlighting pharmacological ligands for their study. Request copy or view PDF today.

divider line

Mechanisms of Addiction

Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs. Request copy or view PDF today.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

New Products in this Area

Oleanolic acid

Selective GPBA receptor (TGR5) partial agonist

PPTN hydrochloride

High affinity and selective P2Y14 antagonist

Itraconazole

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

SAR 216471 hydrochloride

Potent P2Y12 antagonist; orally available

A 971432

Potent and selective S1P5 agonist

GLPG 0974

Potent FFA2 antagonist

Ogerin

Selective positive allosteric modulator at GPR68

BGC 20-1531 hydrochloride

High affinity and selective EP4 antagonist

Montelukast sodium

CysLT1 and GPR17 antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Neuroscience 2016

Neuroscience 2016

November 12 - 16, 2016

San Diego, CA, USA

Booth: 3217