Cat. No. 1245
Chemical Name: (3-Aminopropyl)(diethoxymethyl)phos
Biological ActivitySelective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.
Licensing InformationSold with the permission of Novartis Pharma AG
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Staubli et al (1999) GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 19 4609. PMID: 10341258.
Sutor and Luhmann (1998) Involvement of GABAB receptors in convulsant-induced epileptiform activity in rat neocortex in vitro. Eur.J.Neurosci. 10 3417. PMID: 9824455.
Hao et al (1994) Intrathecal γ-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitisation to mechanical stimuli in the rat. Neurosci.Lett. 182 299. PMID: 7715832.
Olpe et al (1990) CGP 35348: a centrally active blocker of GABAB receptors. Eur.J.Pharmacol. 187 27. PMID: 2176979.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for CGP 35348 include:
Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968. PMID: 24971996.
Gantz et al (2011) Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. J Neurosci 31 12629. PMID: 21880923.
Milenković et al (2007) Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus). J Neurophysiol 98 1634. PMID: 17596413.
Do you know of a great paper that uses CGP 35348 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: CGP 35348, supplier, Brain, penetrant, selective, GABAB, antagonists, Receptors, CGP35348, Tocris Bioscience, GABAB Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Selective GPBA receptor (TGR5) partial agonistPPTN hydrochloride
High affinity and selective P2Y14 antagonistItraconazole
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)SAR 216471 hydrochloride
Potent P2Y12 antagonist; orally availableA 971432
Potent and selective S1P5 agonistGLPG 0974
Potent FFA2 antagonistOgerin
Selective positive allosteric modulator at GPR68BGC 20-1531 hydrochloride
High affinity and selective EP4 antagonistMontelukast sodium
CysLT1 and GPR17 antagonist
November 12 - 16, 2016
San Diego, CA, USA