CGP 35348

Cat. No. 1245

CGP 35348 C8H20NO4P [123690-79-9]

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Chemical Name: (3-Aminopropyl)(diethoxymethyl)phosphinic acid

Biological Activity

Selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M.Wt:
225.22
Formula:
C8H20NO4P
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
123690-79-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Staubli et al (1999) GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 19 4609. PMID: 10341258.

Sutor and Luhmann (1998) Involvement of GABAB receptors in convulsant-induced epileptiform activity in rat neocortex in vitro. Eur.J.Neurosci. 10 3417. PMID: 9824455.

Hao et al (1994) Intrathecal γ-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitisation to mechanical stimuli in the rat. Neurosci.Lett. 182 299. PMID: 7715832.

Olpe et al (1990) CGP 35348: a centrally active blocker of GABAB receptors. Eur.J.Pharmacol. 187 27. PMID: 2176979.

If you know of a relevant reference for CGP 35348 please let us know.

Citations are publications that use Tocris products. Selected citations for CGP 35348 include:

Huang et al (2015) The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Br J Pharmacol 10 413. PMID: 25654758.

Aubdool et al (2014) TRPA1 is essential for the vascular response to environmental cold exposure. Neuron 5 5732. PMID: 25501034.

Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968. PMID: 24971996.

Gantz et al (2013) Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Cell Metab 78 807. PMID: 23764286.

Gantz et al (2011) Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. J Neurosci 31 12629. PMID: 21880923.

Milenković et al (2007) Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus). J Neurophysiol 98 1634. PMID: 17596413.

Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Nat Commun 131 1050. PMID: 11082110.

Do you know of a great paper that uses CGP 35348 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: CGP 35348, supplier, Brain, penetrant, selective, GABAB, antagonists, Receptors, CGP35348, Tocris Bioscience, GABAB Receptor Antagonist products

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