PNU 74654

Cat. No. 3534

PNU 74654 C19H16N2O3 [113906-27-7]

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Chemical Name: 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide

Biological Activity

Binds to β-catenin (KD = 450 nM). Inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway.

Technical Data

M.Wt:
320.34
Formula:
C19H16N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
113906-27-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wells and McClendon (2007) Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 450 1001. PMID: 18075579.

Trosset et al (2006) Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins 64 60. PMID: 16568448.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for PNU 74654 include:

Liao et al (2015) Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nature 47 469. PMID: 25822089.

Tsankov et al (2015) Transcription factor binding dynamics during human ES cell differentiation. Stem Cells Int 518 344. PMID: 25693565.

Yang et al (2015) Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors. Cell Reprogram 2015 270428. PMID: 26089912.

Corritore et al (2014) β-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion. Ann Neurol 16 456. PMID: 25437872.

Baril et al (2013) Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. PLoS Pathog 9 e1003416. PMID: 23785285.

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Keywords: PNU 74654, supplier, PNU74654, beta-catenin, b-catenin, β-catenin, binders, wnt, signalling, signaling, Tocris Bioscience, β-catenin products

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