IWP 2

Cat. No. 3533

IWP 2 C22H18N4O2S3 [686770-61-6]

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Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

Biological Activity

Inhibitor of Wnt processing and secretion. Inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. Suppresses self-renewal in R1 embryonic stem cells.

Technical Data

M.Wt:
466.6
Formula:
C22H18N4O2S3
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
686770-61-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Lian et al (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc.Natl.Acad.Sci.U S A 109 E1848. PMID: 22645348.

ten Berge et al (2011) Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat.Cell.Biol. 13 1070. PMID: 21841791.

Chen et al (2009) Small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer. Nature Chem.Biol. 5 100. PMID: 19125156.

If you know of a relevant reference for IWP 2 please let us know.

Citations are publications that use Tocris products. Selected citations for IWP 2 include:

Ditadi et al (2015) Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Stem Cell Res 17 580. PMID: 25915127.

Freedman et al (2015) Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat Cell Biol 6 8715. PMID: 26493500.

Heylman et al (2015) Supervised Machine Learning for Classification of the Electrophysiological Effects of Chronotropic Drugs on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. PLoS One 10 e0144572. PMID: 26695765.

Huang et al (2015) The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Sci Rep 10 413. PMID: 25654758.

Huebsch et al (2015) Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales. Tissue Eng Part C Methods 21 467. PMID: 25333967.

Kim et al (2015) Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. PLoS One 10 e0118670. PMID: 25706534.

Kumar et al (2015) Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. Elife 4. PMID: 26554899.

Lee et al (2015) A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation. Nat Commun 5 10305. PMID: 25980672.

Lee et al (2015) Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs. Sci Rep 5 11817. PMID: 26139150.

Huang et al (2014) Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol 32 84. PMID: 24291815.

Kempf et al (2014) Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture. Stem Cell Reports 3 1132. PMID: 25454631.

Skelton et al (2014) SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development. Nat Genet 13 172. PMID: 24968096.

Do you know of a great paper that uses IWP 2 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: IWP 2, supplier, MBOAT, membrane-bound, o-acyltransferases, Porcupine, porcn, wnt, secretion, production, signaling, signalling, inhibitors, inhibits, inactivators, inactivates, IWP2, beta-catenin, β-catenin, b-catenin, stem, cell, proliferation, Tocris Bioscience, PORCN Inhibitor products

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