Cat. No. 1297
Alternative Name: Abnormal-cannabidiol
Chemical Name: 4-[(1R,6R)-3-Methyl-6-(1-methylethe
Biological ActivityNeurobehaviorally inactive cannabinoid that acts as a selective agonist for GPR55 (EC50 values are 2.5, >30 and >30 μM at GPR55, CB1 and CB2 receptors respectively). Increases phosphorylation of protein kinases in, and migration of, human umbilical vein endothelial cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302.
Mo et al (2004) Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol. 489 21. PMID: 15063151.
Ho and Hiley (2003) Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery. Br.J.Pharmacol. 138 1320. PMID: 12711633.
Jarai et al (1999) Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc.Natl.Acad.Sci.U.S.A. 96 14136. PMID: 10570211.
If you know of a relevant reference for Abn-CBD please let us know.
Citations are publications that use Tocris products. Selected citations for Abn-CBD include:
Hao et al (2015) Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis. Cell Death Dis 21 38. PMID: 25569804.
Yang et al (2014) Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radic Biol Med 68 260. PMID: 24398069.
Esposito et al (2007) Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 151 1272. PMID: 17592514.
Do you know of a great paper that uses Abn-CBD from Tocris? If so please let us know.
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Keywords: Abn-CBD, supplier, Selective, GPR55, agonists, neurobehaviorally, inactive, Cannabinoids, Receptors, Tocris Bioscience, GPR55 Agonist products
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