CI 966 hydrochloride

Cat. No. 1296

CI 966 hydrochloride C23H21F6NO3.HCl [110283-66-4]

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Chemical Name: 1-[2-[bis[4-(Trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride

Biological Activity

Selective inhibitor of the GABA transporter GAT-1 (IC50 values are 0.26 and 1.2 μM at cloned human and rat GAT-1 respectively). Displays over 200-fold selectivity over GAT-2 and GAT-3. Centrally active upon systemic administration in vivo. Anticonvulsive and neuroprotective.

Technical Data

M.Wt:
509.87
Formula:
C23H21F6NO3.HCl
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
110283-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Borden et al (1994) Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219. PMID: 7851497.

Radulovic et al (1993) Pharmacokinetics, mass balance, and induction potential of novel GABA uptake inhibitor, CI-966 HCl, in laboratory animals. Pharm.Res. 10 1442. PMID: 8272405.

Ebert et al (1990) Systemic CI-966, a new gamma-aminobutyric acid uptake blocker, enhances gamma-aminobutyric acid action in CA1 pyramidal layer in situ. Can.J.Physiol.Pharmacol. 68 1194. PMID: 2276082.

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Keywords: CI 966 hydrochloride, supplier, Selective, inhibitors, inhibits, GAT-1, GABA, Transporters, Monoamine, Neurotransmitter, CI966, hydrochloride, Tocris Bioscience, GABA Inhibitor products

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