Loreclezole hydrochloride

Cat. No. 1295

Loreclezole hydrochloride C10H6Cl3N3.HCl [117857-45-1]

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Chemical Name: (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride

Biological Activity

Subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitization. Inhibits homomeric ρ1 GABAC receptors.

Technical Data

M.Wt:
311
Formula:
C10H6Cl3N3.HCl
Solubility:
Soluble to 5 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
117857-45-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Smith et al (2004) Compounds exhibiting selective efficacy for different β subunits of human recombinant γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 311 601. PMID: 15210837.

Fisher et al (2000) Loreclezole inhibition of recombinant α1β1γ2L GABAA receptor single channel currents. Neuropharmacology 39 235. PMID: 10670419.

Thomet et al (2000) Loreclezole as a simple functional marker for homomeric ρ type GABAC receptors. Eur.J.Pharmacol. 408 R1. PMID: 11080529.

Donnelly and Macdonald (1996) Loreclezole enhances apparent desensitisation of recombinant GABAA receptor currents. Neuropharmacology 35 1233. PMID: 9014138.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Loreclezole hydrochloride include:

Kotak et al (2008) Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex. Mol Med 18 2098. PMID: 18222937.

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Keywords: Loreclezole hydrochloride, supplier, Subtype-selective, GABAA, receptor, modulators, Receptors, positive, allosteric, PAM, Tocris Bioscience, GABAA Receptor Modulator products

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