AT 56

Cat. No. 3531

AT 56 C25H27N5 [162640-98-4]

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Chemical Name: 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine

Biological Activity

Orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki = 75 μM, IC50 = 95 μM). Inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.

Technical Data

Soluble to 50 mM in DMSO
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Irikura et al (2009) Biochemical, functional and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. J.Biol.Chem. 284 7623. PMID: 19131342.

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Citations are publications that use Tocris products. Selected citations for AT 56 include:

Jaurena et al (2015) Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Elife 6 7476. PMID: 26101153.

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Keywords: AT 56, supplier, AT56, L-PGDS, lipocalin-type, prostaglandin, PG, D, synthase, inhibitors, inhibits, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products

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