PD 168568 dihydrochloride

Cat. No. 3529

PD 168568 dihydrochloride C22H27N3O.2HCl [210688-56-5]

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Chemical Name: 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride

Biological Activity

Potent and selective dopamine D4 receptor antagonist (Ki values are 8.8 and 1842 nM at D4 and D2 receptors respectively). Reverses amphetamine-stimulated locomotion in vivo and is orally active.

Technical Data

Soluble to 50 mM in water and to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Belliotti et al (1998) Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg.Med.Chem.Lett. 8 1499. PMID: 9873377.

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Keywords: PD 168568 dihydrochloride, supplier, Potent, selective, D4, antagonists, Dopamine, Receptors, dopaminergic, PD168568, dihydrochloride, Tocris Bioscience, D4 Receptor Antagonist products

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