ZD 7288

Cat. No. 1000

ZD 7288 C15H21ClN4 [133059-99-1]

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Alternative Name: ICI D7288

Chemical Name: 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride

Biological Activity

Sino-atrial node function modulator; blocks the hyperpolarization activated cation current If (HCN channel). Blocks Ih in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Klar et al (2003) Ih channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices. Naunyn Schmiedebergs Arch.Pharmacol. 367 422. PMID: 12690435.

Green et al (1996) Pharmacological characterization of the inwardly rectifying current in the smooth muscle cells of the rat bladder. Br.J.Pharmacol. 119 1509. PMID: 8982495.

Harris and Constanti (1995) Mechanism of block by ZD7288 of the hyperpolarization-activated inward rectifying current in guinea-pig substantia nigra neurons in vitro. J.Neurophysiol. 74 2366. PMID: 8747199.

BoSmith et al (1993) Inhibitory actions of ZENECA ZD7288 on whole cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells. Br.J.Pharmacol. 110 343. PMID: 7693281.

If you know of a relevant reference for ZD 7288 please let us know.

Citations are publications that use Tocris products. Selected citations for ZD 7288 include:

Ghezzi  et al (2016) Electrophysiological characterization of the M-current in rat hypoglossal motoneurons Neuroscience 340 62. PMID: 27984184.

Asteriti et al (2015) A Cambrian origin for vertebrate rods. Elife 4. PMID: 26095697.

Ferreira et al (2015) Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala. PLoS One 9 161. PMID: 25972785.

Kashyap et al (2015) Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation. Front Cell Neurosci 2. PMID: 26709376.

Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. J Neurophysiol 10 e0132884. PMID: 26222156.

Ohno et al (2015) Hcn1 is a tremorgenic genetic component in a rat model of essential tremor. J Neurosci 10 e0123529. PMID: 25970616.

Williams and Hablitz (2015) Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih. Front Cell Neurosci 9 89. PMID: 25852481.

Calejo et al (2014) Hyperpolarization-activated cyclic nucleotide-gated channels and cAMP-dependent modulation of exocytosis in cultured rat lactotrophs. J Neurosci 34 15638. PMID: 25411492.

Dragicevic et al (2014) Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Bladder (San Franc) 137 2287. PMID: 24934288.

Abbas et al (2013) Directional summation in non-direction selective retinal ganglion cells. PLoS Comput Biol 9 e1002969. PMID: 23516351.

Stark et al (2013) Inhibition-induced theta resonance in cortical circuits. Neuron 80 1263. PMID: 24314731.

Zhang et al (2013) Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area. Am J Physiol Endocrinol Metab 305 E1384. PMID: 24105416.

Angelo and Margrie (2012) Population diversity and function of hyperpolarization-activated current in olfactory bulb mitral cells. Sci Rep 1 50. PMID: 22355569.

Few et al (2012) Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A 109 E452. PMID: 22308469.

Patel et al (2012) Frequency-selective exocytosis by ribbon synapses of hair cells in the bullfrog's amphibian papilla. Exp Physiol 32 13433. PMID: 23015434.

Goldberg et al (2011) Rapid developmental maturation of neocortical FS cell intrinsic excitability. J Neurosci 21 666. PMID: 20705896.

Ma et al (2011) High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. J Biomed Sci 301 H2006. PMID: 21890694.

Chen et al (2010) Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice. J Neurosci 30 2611. PMID: 20164346.

Jung et al (2010) Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling. J Neurosci 30 6678. PMID: 20463230.

Bal and Baydas (2009) Electrophysiological properties of octopus neurons of the cat cochlear nucleus: an in vitro study. J Assoc Res Otolaryngol 10 281. PMID: 19277784.

Ballo and Bucher (2009) Complex intrinsic membrane properties and dopamine shape spiking activity in a motor axon. J Neurosci 29 5062. PMID: 19386902.

Zhang et al (2009) Developmental expression of a functional TASK-1 2P domain K+ channel in embryonic chick heart. J Neurosci 16 104. PMID: 19930646.

Molineux et al (2008) Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons. Cereb Cortex 100 2684. PMID: 18768644.

Angelo et al (2007) Local and global effects of I(h) distribution in dendrites of mammalian neurons. Am J Physiol Heart Circ Physiol 27 8643. PMID: 17687042.

Bender et al (2007) Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci 27 4697. PMID: 17460082.

Lee and Ishida (2007) Ih without Kir in adult rat retinal ganglion cells. J Neurophysiol 97 3790. PMID: 17488978.

Lee and Tepper (2007) A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons. J Neurosci 27 6531. PMID: 17567814.

Narushima et al (2007) Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. PLoS One 27 496. PMID: 17234582.

Doan et al (2004) Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers. Brain 24 3335. PMID: 15056713.

Hegg and Lucero (2004) Dopamine reduces odor- and elevated-K(+)-induced calcium responses in mouse olfactory receptor neurons in situ. J Neurophysiol 91 1492. PMID: 14657189.

Do you know of a great paper that uses ZD 7288 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: ZD 7288, supplier, Sino-atrial, node, function, modulators, If, inhibitors, inhibits, Channel, VDAC, ZD7288, ICID7288, AstraZeneca, HCN, Tocris Bioscience, HCN Channel Blocker products

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