Cat. No. 3525


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Chemical Name: Artificial cerebrospinal fluid

Biological Activity

Artificial cerebrospinal fluid (aCSF) commonly used when sampling from brain interstitial fluid. Closely matches the electrolyte concentrations of CSF and is prepared from high purity water and analytical grade reagents. Microfiltered and sterile. Final ion concentrations (in mM): Na 150; K 3.0; Ca 1.4; Mg 0.8; P 1.0; Cl 155.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Byun et al (2012) Induction of neuronal death by microglial AGE-albumin: implications for Alzheimer's disease. PLoS One 7 e37917. PMID: 22662249.

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Citations are publications that use Tocris products. Selected citations for ACSF include:

Lam et al (2016) Absence of systemic oxidative stress and increased CSF prostaglandin F2α in progressive MS Neurology: Neuroimmunology & Neuroinflammation 3 256. PMID: 27386506.

Feetham et al (2015) The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734. Electrophoresis 6 83. PMID: 25954200.

Rau et al (2015) Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress. Nat Commun 35 9730. PMID: 26134655.

Suberbielle et al (2015) DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Front Pharmacol 6 8897. PMID: 26615780.

Taylor et al (2014) Investigating local and long-range neuronal network dynamics by simultaneous optogenetics, reverse microdialysis and silicon probe recordings in vivo. J Neurosci 235 83. PMID: 25004203.

Handa et al (2013) Central 5-α reduction of testosterone is required for testosterone's inhibition of the hypothalamo-pituitary-adrenal axis response to restraint stress in adult male rats. J Neurosci Methods 1529 74. PMID: 23880372.

McCall et al (2013) Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics. Nat Protoc 8 2413. PMID: 24202555.

Phillips and Wellner (2013) Detection of cerebral spinal fluid-associated chemokines in birth traumatized premature babies by chip-based immunoaffinity CE. J Biol Chem 34 1530. PMID: 23512340.

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Keywords: ACSF, supplier, Artificial, cerebrospinal, fluid, Reagents, CSF, Tocris Bioscience, Biochemicals and Molecular Biology products

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