Brain natriuretic peptide (1-32) (human)
Cat. No. 3522
Biological ActivityEndogenous peptide secreted from cardiac ventricles in response to volume increase and pressure overload that acts as an agonist at atrial natriuretic peptide (ANP) receptor A (NRP1). Decreases de novo collagen synthesis and increases MMP gene expression in vitro. Exhibits natriuretic, vasodilatory and lusitropic activity and inhibits the sympathetic and renin-angiotensin-aldosterone systems in vivo.
(Modifications: Disulfide bridge between 10 - 26)
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Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Heublein et al (2007) Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various forms of human B-type natriuretic peptide. Hypertension 49 1114. PMID: 17372040.
Wellard et al (2006) Natriuretic peptides, but not nitric oxide donors, elevate levels of cytosolic guanosine 3',5'-cyclic monophosphate in ependymal cells ex vivo. Neurosci.Lett. 392 187. PMID: 16278044.
Tsuruda et al (2002) Brain natriuretic peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases. Circ.Res. 91 1127. PMID: 12480813.
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Keywords: Brain natriuretic peptide (1-32) (human), supplier, Endogenous, peptide, agonists, ANP, receptor, A, NRP1, Receptors, Atrial, Natriuretic, Peptide, Tocris Bioscience, Natriuretic Peptide Receptor Agonist products
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