Sirtinol

Cat. No. 3521

Sirtinol C26H22N2O2 [410536-97-9]

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Chemical Name: 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide

Biological Activity

Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

Technical Data

M.Wt:
394.47
Formula:
C26H22N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
410536-97-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Jung-Hynes et al (2009) Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J.Biol.Chem. 284 3823. PMID: 19075016.

Kahyo et al (2008) A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J.Pharmacol.Sci. 108 364. PMID: 19008647.

Mai et al (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 48 7789. PMID: 16302818.

Grozinger et al (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J.Biol.Chem. 276 38837. PMID: 11483616.

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Citations are publications that use Tocris products. Selected citations for Sirtinol include:

Balaiya et al (2012) Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α. Mol Vis 18 114. PMID: 22275802.

Paffett et al (2011) Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle. Vascul Pharmacol 56 64. PMID: 22146233.

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Keywords: Sirtinol, supplier, Selective, sirtuin, family, deacetylases, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Tocris Bioscience, Sir 2-like Family Deacetylase Inhibitor products

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