Cat. No. 3518
Chemical Name: 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-
Biological ActivityPartial agonist of α7 nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than memantine (Cat. No. 0773) in Alzheimer's disease mouse models.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with memantine. Psychopharmacology 196 555. PMID: 18034231.
Lagostena et al (2008) The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 54 676. PMID: 18187166.
Marighetto et al (2008) Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 197 499. PMID: 18265960.
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Keywords: S 24795, supplier, S24795, partial, agonist, a7, nAChR, nicotinic, acetylcholine, receptor, α7, agonists, Tocris Bioscience, Nicotinic (α7) Receptor Agonist products
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Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
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