Senktide

Cat. No. 1068

Senktide Succinyl-Asp-Phe-Me-Phe-Gly-Leu-Met-NH2

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Biological Activity

NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.

Technical Data

M.Wt:
841.97
Formula:
C40H55N7O11S
Sequence:
DFFGLM

(Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in PBS (pH 7.4)
Storage:
Desiccate at -20°C
CAS No:
106128-89-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Nordquist et al (2008) The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur.J.Pharmacol. 600 87. PMID: 18930726.

Keegan et al (1992) The selective NK receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br.J.Pharmacol. 105 3. PMID: 1375857.

Renzetti et al (1991) Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [3H]senktide. Neuropeptides 18 107. PMID: 1712430.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Senktide include:

León et al (2016) Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Endocrinology 6 19206. PMID: 26755241.

Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Nat Commun 156 627. PMID: 25422875.

Grachev et al (2012) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. Cereb Cortex 7 e44344. PMID: 23028524.

Gallopin et al (2006) Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. J Neurosci 16 1440. PMID: 16339088.

Howe et al (2004) Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons. Sci Rep 24 10103. PMID: 15537880.

Do you know of a great paper that uses Senktide from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Senktide, supplier, Tachykinin, NK3, agonists, Receptors, Neurokinin, Tocris Bioscience, NK3 Receptor Agonist products

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