Nisoxetine hydrochloride

Cat. No. 1025

Nisoxetine hydrochloride C17H21NO2.HCl [57754-86-6]

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Chemical Name: (±)-γ-(2-Methoxyphenoxy)-N-methylbenzenepropanamine hydrochloride

Biological Activity

A potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.

Technical Data

M.Wt:
307.82
Formula:
C17H21NO2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
57754-86-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Shearman and Meyer (1998) Norepinephrine transporters in rat placenta labeled with [3H]nisoxetine. J.Pharmacol.Exp.Ther. 284 736. PMID: 9454822.

Zhu et al (1997) Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors. J.Neurochem. 68 134. PMID: 8978719.

Cheetham et al (1996) [3H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 35 63. PMID: 8684598.

Wong et al (1975) dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of norepinephrine into rat brain synaptosomes and heart. Life Sci. 17 755. PMID: 1207394.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Nisoxetine hydrochloride include:

Poulin et al (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol 86 378. PMID: 25028482.

Do you know of a great paper that uses Nisoxetine hydrochloride from Tocris? If so please let us know.

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Keywords: Nisoxetine hydrochloride, supplier, Noradrenalin, reuptake, inhibitors, inhibits, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, noradrenaline, Tocris Bioscience, Adrenergic Transporter Inhibitor products

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