Nisoxetine hydrochloride

Cat. No. 1025

Nisoxetine hydrochloride C17H21NO2.HCl [57754-86-6]

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Chemical Name: (±)-γ-(2-Methoxyphenoxy)-N-methylbenzenepropanamine hydrochloride

Biological Activity

A potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.

Technical Data

Soluble to 100 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Shearman and Meyer (1998) Norepinephrine transporters in rat placenta labeled with [3H]nisoxetine. J.Pharmacol.Exp.Ther. 284 736. PMID: 9454822.

Zhu et al (1997) Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors. J.Neurochem. 68 134. PMID: 8978719.

Cheetham et al (1996) [3H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 35 63. PMID: 8684598.

Wong et al (1975) dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of norepinephrine into rat brain synaptosomes and heart. Life Sci. 17 755. PMID: 1207394.

If you know of a relevant reference for Nisoxetine hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Nisoxetine hydrochloride include:

Poulin et al (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol 86 378. PMID: 25028482.

Xu et al (2010) Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant. J Neurosci 115 1643. PMID: 20969573.

Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Front Cell Neurosci 29 15551. PMID: 20007479.

Do you know of a great paper that uses Nisoxetine hydrochloride from Tocris? If so please let us know.

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Keywords: Nisoxetine hydrochloride, supplier, Noradrenalin, reuptake, inhibitors, inhibits, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, noradrenaline, Tocris Bioscience, Adrenergic Transporter Inhibitor products

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