Cat. No. 3507
Alternative Name: Tamibarotene
Chemical Name: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tet
Biological ActivityRetinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Takenaga et al (2009) The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol.Pharm.Bull. 32 225. PMID: 19182380.
Jimi et al (2007) RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int.J.Oncol. 31 397. PMID: 17611697.
Kagechika et al (1988) Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 31 2182. PMID: 3184125.
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Keywords: AM 80, supplier, RARα, RARalpha, agonists, anticancer, Retinoic, Acid, Receptors, AM80, Tocris Bioscience, Retinoic Acid Receptor Agonist products
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