NVP DPP 728 dihydrochloride
Cat. No. 3506
Chemical Name: 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidin
Biological ActivityPotent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (Ki = 11 nM, IC50 = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Exhibits antidiabetic activity in vivo; improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, augments insulin secretion and GLUT2 levels, and reduces (preserves) islet size.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mitani et al (2002) Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. Jpn.J.Pharmacol. 88 451. PMID: 12046989.
Reimer et al (2002) Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. Eur.J.Endocrinol. 146 717. PMID: 11980629.
Hughes et al (1999) NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)-pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry 38 11597. PMID: 10512614.
If you know of a relevant reference for NVP DPP 728 dihydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for NVP DPP 728 dihydrochloride include:
Inoue et al (2012) Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Stem Cell Reports 303 G810. PMID: 22821947.
Do you know of a great paper that uses NVP DPP 728 dihydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: NVP DPP 728 dihydrochloride, supplier, Potent, orally, active, DPP-IV, inhibitors, inhibits, Dipeptidyl, Peptidase, IV, Proteinases, Proteases, NVPDPP728, dihydrochloride, Tocris Bioscience, Dipeptidyl Peptidase IV Inhibitor products
Find multiple products by catalog number
New Products in this Area
Plasminogen activator inhibitor-1 (PAI-1) inhibitorSB 3CT
Selective high affinity MMP2 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.