Cat. No. 3504

Risedronate C7H10NNaO7P2 [115436-72-1]

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Chemical Name: P,P'-[1-Hydroxy-2-(3-pyridonyl)ethylidene]bis-phosphonic acid sodium salt

Biological Activity

Orally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase (IC50 = 100 nM). Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone resorption in vivo.

Technical Data

Soluble to 10 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fournier et al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic stragey to optimize skeletal tumor growth inhibition in vivo. Cancer Res. 68 8945. PMID: 18974139.

Stresing et al (2007) Bisphosphonates in cancer therapy. Cancer Letts. 257 16. PMID: 17697748.

Coxon et al (2006) Recent advances in understanding the mechanism of action of bisphosphonates. Curr.Opin.Pharmacol. 6 307. PMID: 16650801.

Dunford et al (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 296 235. PMID: 11160603.

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Keywords: Risedronate, supplier, Farnesyl, diphosphate, FPP, inhibitors, inhibits, Synthases, Synthetases, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products

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