Cat. No. 3504
Chemical Name: P,P'-[1-Hydroxy-2-(3-pyridonyl)ethyl
Biological ActivityOrally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase. Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone reabsorption in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fournier et al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic stragey to optimize skeletal tumor growth inhibition in vivo. Cancer Res. 68 8945. PMID: 18974139.
Stressing et al (2007) Bisphosphonates in cancer therapy. Cancer Letts. 257 16.
Coxon et al (2006) Recent advances in understanding the mechanism of action of bisphosphonates. Curr.Opin.Pharmacol. 6 307. PMID: 16650801.
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Keywords: Risedronate, supplier, Farnesyl, diphosphate, FPP, inhibitors, inhibits, Synthases, Synthetases, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products