Cat. No. 3503
Chemical Name: 5-[[3-Dimethylamino)propyl]amino]-3
Biological ActivityInhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yang et al (2009) Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 100 24. PMID: 19037995.
Kitagaki et al (2008) Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol.Cancer Ther. 7 2445. PMID: 18723490.
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Keywords: HLI 373, supplier, Hdm2, inhibitors, inhibits, inhibitor, p53, transcription, activators, HLI373, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
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