Cat. No. 3503
Chemical Name: 5-[[3-Dimethylamino)propyl]amino]-3
Biological ActivityInhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Yang et al (2009) Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 100 24. PMID: 19037995.
Kitagaki et al (2008) Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol.Cancer Ther. 7 2445. PMID: 18723490.
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Keywords: HLI 373, supplier, Hdm2, inhibitors, inhibits, inhibitor, p53, transcription, activators, HLI373, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products