HLI 373

Cat. No. 3503

HLI 373 C18H23N5O2.2HCl [502137-98-6]

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Chemical Name: 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride

Biological Activity

Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.

Technical Data

M.Wt:
414.33
Formula:
C18H23N5O2.2HCl
Solubility:
Soluble to 100 mM in water and to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
502137-98-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yang et al (2009) Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 100 24. PMID: 19037995.

Kitagaki et al (2008) Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol.Cancer Ther. 7 2445. PMID: 18723490.

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Keywords: HLI 373, supplier, Hdm2, inhibitors, inhibits, inhibitor, p53, transcription, activators, HLI373, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products

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