Cat. No. 3502
Alternative Name: Patupilone
Chemical Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dih
Biological ActivityMicrotubule stabilization agent that promotes tubulin polymerization and induces G2-M cell cycle arrest (EC50 = 32 nM in HeLa cells). Inhibits proliferation of human carcinoma cell lines in vitro, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent cytotoxicity in MCF-7 and A549 cells (EC50 values are 0.3 and 2.7 nM respectively). Inhibits growth of HCT-15 tumors in mice in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Narvi et al (2013) Altered TUBB3 expression contributes to the epothilone response of mitotic cells. Br.J.Cancer 108 82. PMID: 23321512.
O'Reilly et al (2008) Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo. Cancer Chemother.Pharmacol. 62 1045. PMID: 18301895.
Altmann et al (2000) Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochim.Biophys.Acta 1470 M79. PMID: 10799747.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Epothilone B from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Epothilone B, supplier, Microtubule, stabilization, agent, promotes, tubulin, polymerization, G2-M, cell, cycle, arrest, Tau, Tubulin, Mitosis, EpothiloneB, Tocris Bioscience, Microtubule products
Find multiple products by catalog number
November 12 - 16, 2016
San Diego, CA, USA