Cat. No. 3548
Chemical Name: 3,4-Dihydroxyphenethylamine hydrochloride
Biological ActivityEndogenous neurotransmitter that acts as an agonist at dopamine D1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis. Caged dopamine is also available (Cat. No 3992).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Cools (2008) Role of dopamine in the motivational and cognitive control of behavior. Neuroscientist 14 381. PMID: 18660464.
Fitzgerald and Dinan (2008) Prolactin and dopamine: what is the connection? A review article. J.Psychopharmacol. 22 S12.
Rivonello et al (2007) Novel insights into dopamine receptor pharmacology. Eur.J.Endocrinol. 156 S13. PMID: 17413183.
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Citations are publications that use Tocris products. Selected citations for Dopamine hydrochloride include:
Brzosko et al (2015) Retroactive modulation of spike timing-dependent plasticity by dopamine. Elife 4. PMID: 26516682.
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.
Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192. PMID: 26074768.
Zheng et al (2014) Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. Physiol Res 306 R138. PMID: 24305061.
Zhang et al (2013) Sucrose produces withdrawal and dopamine-sensitive reinforcing effects in planarians. Physiol Behav 112-113 8. PMID: 23415661.
Kučka et al (2012) Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs. World J Gastroenterol 61 267. PMID: 22480423.
O'Keeffe et al (2009) Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc Natl Acad Sci U S A 106 8754. PMID: 19433789.
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Keywords: Dopamine hydrochloride, supplier, Endogenous, agonists, dopamine, D1, receptors, Dopamine, D2, D3, Non-Selective, Receptors, D5, dopaminergic, TAAR1, Tocris Bioscience, D1 and D5 Receptor Agonist products