Histamine dihydrochloride

Cat. No. 3545

Histamine dihydrochloride C5H9N3.2HCl [56-92-8]

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Chemical Name: 2-(4-Imidazolyl)ethylamine dihydrochloride

Biological Activity

Endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.

Technical Data

M.Wt:
184.07
Formula:
C5H9N3.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at RT
CAS No:
56-92-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Thurmond et al (2008) The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat.Rev.Drug Discov. 7 41. PMID: 18172439.

Maintz and Novak (2007) Histamine and histamine intolerance. Am.J.Clin.Nutr. 85 1185. PMID: 17490952.

Hill et al (1997) International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol.Rev. 49 253. PMID: 9311023.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Histamine dihydrochloride include:

Femenia et al (2015) Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. Int J Neuropsychopharmacol 18. PMID: 25762718.

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.

Do you know of a great paper that uses Histamine dihydrochloride from Tocris? If so please let us know.

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Keywords: Histamine dihydrochloride, supplier, Endogenous, histamine, receptor, agonists, H4, Receptors, Histamine, H1, H2, H3, histaminergic, Tocris Bioscience, Histamine H1 Receptor Agonist products

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