ML 10302 hydrochloride

Cat. No. 3499

ML 10302 hydrochloride C15H21ClN2O3.HCl [186826-17-5]

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Chemical Name: 4-Amino-5-chloro-2-methoxybenzoic acid 2-(1-piperidinyl)ethyl ester hydrochloride

Biological Activity

Potent 5-HT4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over 5-HT3 receptors (Ki values are 1.07 and 730 nM respectively). Increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo.

Technical Data

M.Wt:
349.25
Formula:
C15H21ClN2O3.HCl
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
186826-17-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cachard-Chastel et al (2007) 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br.J.Pharmacol. 150 883. PMID: 17325649.

Ponti et al (2001) Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol.Mot. 13 543.

Yang et al (1997) New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J.Med.Chem. 40 608. PMID: 9046352.

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Keywords: ML 10302 hydrochloride, supplier, Potent, selective, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, ML10302, hydrochloride, Tocris Bioscience, 5-HT4 Receptor Agonist products

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