Cat. No. 3498
Biological ActivityIntegrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Droppelmann et al (2009) Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin. J.Biol.Chem. 284 13551. PMID: 19276073.
Moon et al (2009) Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir.Res. 10 18. PMID: 19272161.
Grigoriou et al (2005) Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J.Biol.Chem. 280 1733. PMID: 15522882.
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Citations are publications that use Tocris products. Selected citations for RGDS peptide include:
Ahmed et al (2015) Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells. J Radiat Res 2 85. PMID: 25692127.
Kang et al (2012) Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice. J Neurosci 32 9277. PMID: 22764235.
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Keywords: RGDS peptide, supplier, Integrin, binding, sequence, inhibits, inhibitors, Receptors, Adhesion, Molecules, Tocris Bioscience, Integrin Inhibitor products
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