TRAP-6

Cat. No. 3497

TRAP-6 Ser-Phe-Leu-Leu-Arg-Asn

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Alternative Name: Thrombin receptor activator peptide 6

Biological Activity

Peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 μM), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.

Technical Data

M.Wt:
748.88
Formula:
C34H56N10O9
Sequence:
SFLLRN
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
141136-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Hunter et al (2009) Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J.Biol.Chem. 284 12339. PMID: 19261611.

Kaufmann et al (1999) PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 42 131. PMID: 10421070.

Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 267 6081. PMID: 1313429.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for TRAP-6 include:

Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912. PMID: 24876278.

Yan et al (2013) Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage. Front Bioeng Biotechnol 44 1410. PMID: 23539525.

Do you know of a great paper that uses TRAP-6 from Tocris? If so please let us know.

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Keywords: TRAP-6, supplier, PAR1, peptide, fragment, residues, 42-47, agonists, Receptors, Protease-Activated, proteinase-activated, Thrombin, receptor, activator, peptide6, Tocris Bioscience, Protease-Activated Receptor Agonist products

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