Cat. No. 3497
Alternative Name: Thrombin receptor activator peptide 6
Biological ActivityPeptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 μM), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Hunter et al (2009) Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J.Biol.Chem. 284 12339. PMID: 19261611.
Kaufmann et al (1999) PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 42 131. PMID: 10421070.
Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 267 6081. PMID: 1313429.
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Citations are publications that use Tocris products. Selected citations for TRAP-6 include:
Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912. PMID: 24876278.
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Keywords: TRAP-6, supplier, PAR1, peptide, fragment, residues, 42-47, agonists, Receptors, Protease-Activated, proteinase-activated, Thrombin, receptor, activator, peptide6, Tocris Bioscience, Protease-Activated Receptor Agonist products
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San Diego, CA, USA