Cat. No. 3495
Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-p
Biological ActivityPurine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Meng et al (2007) Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo. Eur.J.Haematol. 79 486. PMID: 17976186.
Torella et al (2007) Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am.J.Physiol.Heart Circ.Physiol. 292 H2935. PMID: 17293493.
Bellosillo et al (1999) In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood 94 2836. PMID: 10515887.
Frank et al (1999) Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat.Med. 5 444. PMID: 10202937.
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Citations are publications that use Tocris products. Selected citations for Fludarabine include:
Odendall et al (2014) Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nat Immunol 15 717. PMID: 24952503.
Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641. PMID: 24265703.
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Keywords: Fludarabine, supplier, Purine, analog, inhibits, inhibitors, DNA, synthesis, Proapoptotic, increases, Bax, decreases, Bid, XIAP, survivin, expression, Apoptosis, Inducer, STAT1, chemotherapeutics, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
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November 12 - 16, 2016
San Diego, CA, USA