Cyclosomatostatin

Cat. No. 3493

Cyclosomatostatin cyclo(Aminoheptanoyl-Phe-DTrp-Lys-(Bn)Thr)

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Alternative Name: Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL])

Biological Activity

Non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.

Technical Data

M.Wt:
779.98
Formula:
C44H57N7O6
Sequence:
FWKT

(Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-1 = DTrp, Thr-4 = Bn-Thr)

Solubility:
Soluble to 1 mg/ml in 20% ethanol / water
Storage:
Store at -20°C
CAS No:
84211-54-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Guo et al (2008) Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat. Brain Res. 1229 61. PMID: 18640104.

Stirnweis et al (2002) The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist. Peptides 23 1503. PMID: 12182954.

Fries et al (1982) Somatostatin antagonist analog increases GH, insulin, and glucagon release in the rat. Peptides 3 811. PMID: 6129618.

If you know of a relevant reference for Cyclosomatostatin please let us know.

Citations are publications that use Tocris products. Selected citations for Cyclosomatostatin include:

Elliott et al (2015) Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130. PMID: 25406263.

Do you know of a great paper that uses Cyclosomatostatin from Tocris? If so please let us know.

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Keywords: Cyclosomatostatin, supplier, Non-Selective, sst, receptor, antagonists, Receptors, Somatostatin, Tocris Bioscience, Somatostatin (sst) Receptor Antagonist products

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