Cat. No. 3492
Alternative Name: Adrenocorticotropic hormone (1-39)
Biological ActivityPotent endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Bertolini et al (2009) Brain effects of melanocortins. Pharmacol.Res. 59 13. PMID: 18996199.
Iwen et al (2008) Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes. J.Endocrinol. 196 465. PMID: 18310442.
Kapas et al (1996) Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 137 3291. PMID: 8754753.
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Keywords: ACTH (1-39), supplier, Potent, endogenous, MC2R, agonists, Receptors, Melanocortin, acethropan, Tocris Bioscience, Melanocortin (MC) Receptor Agonist products
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