Prion Protein 106-126 (human)

Cat. No. 3491

Prion Protein 106-126 (human) Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly

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Biological Activity

Prion peptide fragment that shares many physiochemical features with PrPSc. Exhibits neurotoxicity caused by amplification of PrPC-associated signaling responses and induces NF-κB-mediated apoptosis in the mouse neuroblastoma cell line N2a. Forms β-sheet-rich, insoluble, protease-resistant fibrils and is used as a model to study prion diseases in vitro.

Technical Data

M.Wt:
1912.26
Formula:
C80H138N26O24S2
Sequence:
KTNMKHMAGAAAAGAVVGGLG
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
148439-49-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bai et al (2008) p75NTR activation of NF-κB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells. Neurosci.Res. 62 9. PMID: 18602709.

Pietri et al (2006) Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. J.Biol.Chem. 281 28470. PMID: 16864581.

Forloni et al (1993) Neurotoxicity of a prion protein fragment. Nature 362 543. PMID: 8464494.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Prion Protein 106-126 (human) include:

Domizio et al (2012) Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid. J Biol Chem 287 736. PMID: 22102410.

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Keywords: Prion Protein 106-126 (human), supplier, Prion, protein, fragment, PrPSc, Antiprion, Neuronal, Metabolism, Tocris Bioscience, Neuronal Metabolism products

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