Telenzepine dihydrochloride

Cat. No. 1122

Telenzepine dihydrochloride C19H22N4O2S.2HCl [147416-96-4]

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Chemical Name: 4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride

Biological Activity

Selective high affinity muscarinic M1 receptor antagonist (Ki = 0.94 nM). Inhibits gastric acid secretion.

Technical Data

M.Wt:
443.39
Formula:
C19H22N4O2S.2HCl
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
147416-96-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Christofi et al (1991) Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine. Eur.J.Pharmacol. 195 333. PMID: 1868879.

Galvan et al (1989) Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia. Eur.J.Pharmacol. 167 1. PMID: 2776837.

Eltze et al (1985) Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug. Eur.J.Pharmacol. 112 211. PMID: 4029260.

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Citations are publications that use Tocris products. Selected citations for Telenzepine dihydrochloride include:

Pediani et al (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. J.Biol.Chem. 291 13132. PMID: 27080256.

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Keywords: Telenzepine dihydrochloride, supplier, Potent, selective, M1, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, Tocris Bioscience, M1 Receptor Antagonist products

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