SB 216641 hydrochloride

Cat. No. 1242

SB 216641 hydrochloride C28H30N4O4.HCl [193611-67-5]

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Chemical Name: N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride

Biological Activity

A selective h5-HT1B antagonist with approximately 25-fold selectivity over h5-HT1D and little or no affinity for a range of other receptor types.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:
523.03
Formula:
C28H30N4O4.HCl
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
193611-67-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Hagan et al (1997) Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur.J.Pharmacol. 331 169. PMID: 9274976.

Price et al (1997) SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 312. PMID: 930567.

Schlicker et al (1997) Effects of selective h5-HT1B (SB-216641) and 5-HT1D (BRL-15572) receptor ligands on guinea pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 321. PMID: 9303568.

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Citations are publications that use Tocris products. Selected citations for SB 216641 hydrochloride include:

Soll et al (2012) Expression of serotonin receptors in human hepatocellular cancer. Clin Cancer Res 18 5902. PMID: 23087410.

Dunbar et al (2010) Endogenous extracellular serotonin modulates the spinal locomotor network of the neonatal mouse. J Physiol 588 139. PMID: 19884315.

Watakabe et al (2009) Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. J Biol Chem 19 1915. PMID: 19056862.

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Keywords: SB 216641 hydrochloride, supplier, Selective, h5-HT1B, antagonist, Serotonin, Receptors, SB216641, hydrochloride, GlaxoSmithKline, GSK, Tocris Bioscience, 5-HT1B Receptor Antagonist products

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